
Science
Use physics-based design to advance
- Biomolecular target exploration
- Hit identification, hit-to-lead, and lead optimization
- Free energy predictions
- Pharmaceutical formulations

Speed
Break the speed barrier searching billions of available molecules
- Ligand- and structure-based virtual screening
- Molecular dynamics (MD) simulations
- Affinity predictions
- Quantum chemistry calculations
2D similarity search on billions of ligands in
Seconds
3D similarity search on billions of ligands in
Minutes
Dock billions of ligands in
Hours
Scale
Accelerate science to the speed of now
- Screen ultra-large scale compound databases
- Perform long timescale MD simulations on large systems
- Improve impact using rigorous theory & efficient algorithms
- Design & screen antibody libraries using NGS
Cadence Announces New Life Sciences Leadership
miniWebinar: Opening up the druggable universe one cryptic pocket at a time
Essentials of Computational Drug Discovery - Complimentary Access
New Year’s 2025 Fireside Chat with Anthony Nicholls
miniWebinar: Optimizing lead compounds with efficient binding free energy calculations
miniWebinar: Opening up the druggable universe one cryptic pocket at a time
Essentials of Computational Drug Discovery - Complimentary Access
New Year’s 2025 Fireside Chat with Anthony Nicholls
miniWebinar: Optimizing lead compounds with efficient binding free energy calculations
Resources
Glimpse the Future through News, Events, Webinars and more
News
Cadence Announces New Life Sciences Leadership
Cadence Molecular Sciences (OpenEye) (CMS)—a business unit of Cadence Design Systems, Inc. Corporate Vice President, Anthony Nicholls, PhD, has announced his retirement as of January, 2025.
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Webinar
miniWebinar: Opening up the druggable universe one cryptic pocket at a time
In our first miniWEBINAR of 2025 we were talking about a computational workflow to validate difficult-to-drug protein targets in "Opening up the druggable universe one cryptic pocket at a time" session presented by David LeBard, Head of Enhanced Sampling at OpenEye, Cadence Molecular Sciences,
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